FITC标记的磷酸化胞浆型磷脂酶A2抗体
产品名称： FITC标记的磷酸化胞浆型磷脂酶A2抗体
英文名称： Anti-phospho-CPLA2 (Ser505)/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-CPLA2 (Ser505)/FITC Conjugated antibody
FITC标记的磷酸化胞浆型磷脂酶A2抗体
| 产品编号 | bs-8572R-FITC |
| 英文名称 | Anti-phospho-CPLA2 (Ser505)/FITC |
| 中文名称 | FITC标记的磷酸化胞浆型磷脂酶A2抗体 |
| 别 名 | CPLA2(phospho-Ser505); CPLA2(phospho-S505); p-CPLA2 (Ser505); p-CPLA2 (S505); Calcium dependent phospholipid binding protein; CPLA 2; cPLA2 alpha; cPLA2; Cytosolic phospholipase A2; Cytosolic phospholipase A2 group IVA; Lysophospholipase; MGC126350; PA24A_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group 4 A; Phospholipase A2 group IVA (cytosolic calcium dependent); Phospholipase A2 group IVA; PhospholipaseA2; PLA2G4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 82kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human CPLA2 around the phosphorylation site of Ser505 [PL(p-S)PL] |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]. Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Subunit: Interacts with KAT5. Subcellular Location: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Tissue Specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Post-translational modifications: Activated by phosphorylation at both Ser-505 and Ser-727. Similarity: Contains 1 C2 domain. Contains 1 PLA2c domain. Database links: UniProtKB/Swiss-Prot: P47712.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码胞浆磷脂酶A2 IV族成员。酶催化膜磷脂水解，释放花生四烯酸，随后代谢为二十碳五烯酸。花生四烯酸，包括前列腺素和白三烯，是基于脂质的细胞，调节血流动力学，炎症反应，和其他细胞内途径。水解反应还产生溶血磷脂，转化为血小板活化因子。该酶通过细胞内Ca（2 +）水平的增加和磷酸化而激活，导致其从细胞质和细胞核转运到核周膜囊泡。[ RefSeq，JUL 2008 ]提供。