CDK2 (C-term) Peptide
产品名称： CDK2 (C-term) Peptide
英文名称： CDK2 (C-term) Peptide
产品编号： P2523
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.
Moshinsky DJ, Bellamacina CR, Boisvert DC, Huang P, Hui T, Jancarik J, Kim SH, Rice AG.Biochem Biophys Res Commun. 2003 Oct 24;310(3):1026-31.
- 2.
- Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2.
O'Nions J, Allday MJ.Oncogene. 2003 Oct 16;22(46):7181-91.
- 3.
- Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
Chow JP, Siu WY, Ho HT, Ma KH, Ho CC, Poon RY.J Biol Chem. 2003 Oct 17;278(42):40815-28. Epub 2003 Aug 11.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDK2 polyclonal antibody (Cat # PAB2912) in Jurkat cell line lysates (35 ug/lane). CDK2 (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with CDK2 polyclonal antibody (Cat # PAB2912) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 1017
- Protein Accession#:
- P24941
- Gene Name:
- CDK2
- Gene Alias:
- p33(CDK2)
- Gene Description:
- cyclin-dependent kinase 2
- Omim ID:
- 116953
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq
- Other Designations:
- cdc2-related protein kinase,cell devision kinase 2,p33 protein kinase
- Interactome
