KIR3DL1 Pre-design Chimera RNAi
产品名称： KIR3DL1 Pre-design Chimera RNAi
英文名称： KIR3DL1 Pre-design Chimera RNAi
产品编号： H00003811-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_013289
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 3811
- Gene Name:
- KIR3DL1
- Gene Alias:
- CD158E1,KIR,MGC119726,MGC119728,MGC126589,MGC126591,NKAT3,NKB1,NKB1B
- Gene Description:
- killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
- Other Designations:
- KIR antigen 3DL1,NK-receptor,killer cell immunoglobulin-like receptor 3DL1,natural killer-associated transcript 3,p70 killer cell inhibitory receptor
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Autoimmune Diseases
- Behcet Syndrome
- Carcinoma, Hepatocellular
- Cervical Intraepithelial Neoplasia
- Chronic Disease
- Colorectal Neoplasms
- Cytomegalovirus Infections
- Diabetes Mellitus, Type 1
- Disease Progression
- Familial Mediterranean Fever
- Familial Mediterranean fever
- Gastritis
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Graves Disease