FITC标记的对接蛋白4抗体
产品名称： FITC标记的对接蛋白4抗体
英文名称： Anti-DOK4/FITC
产品编号： HZ-11826R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DOK4/FITC Conjugated antibody
FITC标记的对接蛋白4抗体
| 英文名称 | Anti-DOK4/FITC |
| 中文名称 | FITC标记的对接蛋白4抗体 |
| 别 名 | docking protein 4; Downstream of tyrosine kinase 4; FLJ10488; DOK4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DOK4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis. Function: DOK4 (docking protein 4) belongs to the family of docking proteins which interact with receptor tyrosine kinases and mediate particular biological responses. DOK4 functions in RET mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Subunit: Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity). Tissue Specificity: Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. Post-translational modifications: Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. Similarity: Belongs to the DOK family. Type B subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q8TEW6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
激酶家族的下游(Dok-1-7)是一类与受体酪氨酸激酶相互作用的对接蛋白的成员，并且通过这种相互作用介导体内的生物学反应。Dok-4(Kiase-4的下游)是含有一个PH结构域和一个IRS型PTB结构域的326个氨基酸蛋白，属于Dok相互作用蛋白家族。Dok-4在肝脏、心脏、肾脏和骨骼肌中表达量最高，在Ret介导的神经突起生长中起着重要作用，在神经元分化过程中可能与下游效应因子有关。此外，Dok-4被认为在MAPK途径的激活中起着积极作用，并可能参与T细胞诱导的免疫系统调节。DOK-4的过度表达与肾透明细胞癌相关，提示DOK-4在肿瘤发生中的作用。