FITC标记的GRC5蛋白抗体
产品名称： FITC标记的GRC5蛋白抗体
英文名称： Anti-GRC5/FITC
产品编号： HZ-11659R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GRC5/FITC Conjugated antibody
FITC标记的GRC5蛋白抗体
| 产品编号 | bs-11659R-FITC |
| 英文名称 | Anti-GRC5/FITC |
| 中文名称 | FITC标记的GRC5蛋白抗体 |
| 别 名 | CENP-35; GRC5; PHF2; JHDM1E; Jumonji C domain containing histone demethylase 1E; jumonji containing protein; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRC5/PHF2 (1001-1096aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PHF2 is a 1,101 amino acid protein belonging to the PHD finger protein family. Members of the PHD finger protein family function as transcriptional regulators that affect gene expression by modulating chromatin structure. Expressed in a wide variety of tissues, PHF2 localizes to the nucleus and contains one PHD-type zinc finger and one JMJC domain, suggesting a possible role for PHF2 in transcription regulation and chromatin remodeling. The gene encoding PHF2 lies in the candidate region for hereditary sensory neuropathy type I (HSN1), a disorder characterized by sensory dysfunction. PHF2 exhists as two isoforms produced by alternative splicing, designated isoform 1 and 2 respectively. Function: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Subunit: Component of the PHF2-ARID5B complex, at least composedof PHF2 and ARID5B. Interacts with HNF4A and NR1H4. Subcellular Location: Nucleus, nucleolus. Tissue Specificity: Widely expressed, including in liver (at protein level). Post-translational modifications: Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex. Similarity: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger. Database links: Entrez Gene: 5253 Human Entrez Gene: 18676 Mouse Entrez Gene: 306814 Rat Omim: 604351 Human SwissProt: O75151 Human SwissProt: Q9WTU0 Mouse
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PHF2是属于PHD指蛋白家族的1101氨基酸。PHD指蛋白家族成员作为转录调控因子，通过调节染色质结构影响基因表达。在多种组织中表达，PHF2定位到细胞核，并包含一个PHD型锌指和一个JMJC结构域，提示PHF2在转录调控和染色质重塑中可能发挥的作用。编码PHF2的基因位于遗传性感觉神经病I型（HSN1）的候选区域，该疾病以感觉功能障碍为特征。PHF2表现为由选择性剪接产生的两种异构体，分别为1和2。