Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Human B cell Activating Factor/TNFSF13B
                
(Human BAFF/TNFSF13B)
                
                

                
90604ES08
                
                

                
5μg
                
                

                
815.00
                
            
            

                

                
90604ES60
                
                

                
100μg
                
                

                
11125.00
                
            
            

                

                
90604ES76
                
                

                
500μg
                
                

                
35395.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF. BAFF binds to three receptors, BAFF-R, transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), and B cell maturation Ag (BCMA). BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells. BAFF also promotes monocyte survival, proinflammatory cytokine secretion, and differentiation to macrophage.
    
 
    
Product Properties
    
 
    

    

            

                

                    

                        

                            
                        
                    
                
            
        





























        

            

                

                
Synonyms
                
                

                
BLyS, CD257, TNFSF13B, TNFSF20, TALL-1, BLys, THANK, BAFFB-cell activating factor, ZTNF4
                
            
            

                

                
Accession
                
                

                
Q9Y275
                
            
            

                

                
GeneID
                
                

                
10673
                
            
            

                

                
Source
                
                

                
E.coli-derived Human BAFF, Ala134-Leu285, with an N-terminal Met.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 17.2 kDa.
                
            
            

                

                
AA Sequence
                
                

                
MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                

                
Physical Appearance
                
                

                
Sterile Filtered White lyophilized (freeze-dried) powder.
                
            
            

                

                
Purity
                
                

                
>95% by SDS-PAGE and HPLC analyses.
                
            
            

                

                
Biological Activity