分子量：Calculated MW: 83kDa/88kDa
Observed MW: 84KDa

细胞定位：Lumenal side, Peripheral membrane protein, Rough endoplasmic reticulum membrane

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.