FITC标记的β淀粉样前体蛋白结合蛋白2抗体（X11β）
产品名称： FITC标记的β淀粉样前体蛋白结合蛋白2抗体（X11β）
英文名称： Anti-APBA2/FITC
产品编号： HZ-11651R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-APBA2/FITC Conjugated antibody
FITC标记的β淀粉样前体蛋白结合蛋白2抗体（X11β）
| 产品编号 | bs-11651R-FITC |
| 英文名称 | Anti-APBA2/FITC |
| 中文名称 | FITC标记的β淀粉样前体蛋白结合蛋白2抗体（X11β） |
| 别 名 | Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11l. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 82kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APBA2 (351-450aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3). Function: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Subunit: Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Tissue Specificity: Brain. Similarity: Contains 2 PDZ (DHR) domains. Contains 1 PID domain. Database links: UniProtKB/Swiss-Prot: Q99767.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
β淀粉样蛋白前体蛋白（β-APP）是阿尔茨海默病患者淀粉样蛋白沉积的主要成分。已知β淀粉样蛋白前体与多种蛋白质相互作用，包括X11和G异三聚体蛋白APP-BP1。已知神经元、跨膜蛋白X11通过磷酸酪氨酸结合（PTB）结构域与β-淀粉样前体蛋白结合，减少细胞βAPP的分泌和减慢β-APP处理途径。X11具体绑定到YnpTy基序，这涉及到内化的βAPP。已经识别出X11的多个剪接变异体，包括X11α（也被指定为薄荷1）、X11β（薄荷2）和X11γ（薄荷3）。