重组小鼠Fas(TNFRSF6)(CD95)(C端His标签)

中文名称：重组小鼠Fas(TNFRSF6)(CD95)(C端His标签)
英文名称：Recombinant Mouse Apoptosis-mediating Surface Antigen FAS
产品规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln22-Arg169在C端含有His标签。

Fas/TNFRSF6/CD95质量控制：＞95%(还原性SDS-PAGE)

Fas/TNFRSF6/CD95制剂：冻干品

Fas/TNFRSF6/CD95保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Fas/TNFRSF6/CD95复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Fas/TNFRSF6/CD95：
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. 

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