FITC标记的丝氨酸/苏氨酸蛋白激酶Nek3抗体
产品名称： FITC标记的丝氨酸/苏氨酸蛋白激酶Nek3抗体
英文名称： Anti-NEK3/FITC
产品编号： HZ-6261R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-NEK3/FITC Conjugated antibody
FITC标记的丝氨酸/苏氨酸蛋白激酶Nek3抗体
| 英文名称 | Anti-NEK3/FITC |
| 中文名称 | FITC标记的丝氨酸/苏氨酸蛋白激酶Nek3抗体 |
| 别 名 | HSPK 36; HSPK36; HSPK-36; NEK3; NEK 3; NEK-3; NEK3_HUMAN; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a) related kinase 3; NimA related protein kinase 3; NimA-related protein kinase 3; Serine/threonine protein kinase Nek3; Serine/threonine-protein kinase Nek3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEK3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar2009]. Function: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. Subunit: Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent. Subcellular Location: Cytoplasm (By similarity). Cell projection, axon (By similarity). Tissue Specificity: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain. Post-translational modifications: Phosphorylation at Thr-479 regulates its catalytic activity (By similarity). Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: P51956.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码一个成员的NIMA（从来没有在有丝分裂A）的丝氨酸/苏氨酸蛋白激酶家族。编码的蛋白质不同于其他NimA家族成员，因为它不是细胞周期调控的，主要存在于细胞质中。激酶被催乳素刺激激活，导致VAV2鸟嘌呤核苷酸交换因子磷酸化、帕西林磷酸化和RAC1-GTP酶的活化。对该基因已发现编码不同亚型的多个转录变体。[ RefSeq，MARS2009提供]。