FITC标记的8号染色体开放阅读框37抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的8号染色体开放阅读框37抗体

FITC标记的8号染色体开放阅读框37抗体

商家询价

产品名称： FITC标记的8号染色体开放阅读框37抗体

英文名称： Anti-C8orf37/FITC

产品编号： HZ-15288R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-C8orf37/FITC Conjugated antibody

FITC标记的8号染色体开放阅读框37抗体

 

英文名称 Anti-C8orf37/FITC
中文名称 FITC标记的8号染色体开放阅读框37抗体
别    名 C8orf37; CH037_HUMAN; Uncharacterized protein C8orf37.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C8orf37
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. The C8orf37 gene product has been provisionally designated C8orf37 pending further characterization.

Subcellular Location:
ytoplasm. Note=In the retina, located at the base of the primary cilium. 

Tissue Specificity:
Widely expressed, with highest levels in heart and brain. Also expressed in the retina (at protein level).

DISEASE:
Defects in C8orf37 are the cause of cone-rod dystrophy type 16 (CORD16) [MIM:614500]. An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
Defects in C8orf37 are the cause of retinitis pigmentosa type 64 (RP64) [MIM:614500]. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Database links:
UniProtKB/Swiss-Prot: Q96NL8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

由近1亿4600万个碱基组成，8号染色体编码约800个基因。对8号染色体与c-myc基因扩增部分易位在某些白血病和淋巴瘤的发现，通常与不良预后。8号染色体的部分与精神分裂症和双相情感障碍有关。Warkany 8三体综合征，又称综合征2，最常在早期流产的结果不过是在马赛克的形式存活的患者有不同程度的一些症状包括精神运动发育迟缓偶尔看到的，和某些面部发育缺陷WRN是由8号染色体编码的DNA解旋酶，在早期衰老障碍沃纳综合征中显示出缺陷。第8号染色体也与菲佛综合征、先天性甲状腺功能减退症和Waord-Burg综合征有关。C8ORF37基因产物已暂时指定为C8OF37，有待进一步鉴定。