FITC标记的肽基脯氨酰顺反异构酶FKBP12抗体
产品名称： FITC标记的肽基脯氨酰顺反异构酶FKBP12抗体
英文名称： Anti-FKBP-1A/FKBP12/FITC
产品编号： HZ-7450R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FKBP-1A/FKBP12/FITC Conjugated antibod
FITC标记的肽基脯氨酰顺反异构酶FKBP12抗体
| 英文名称 | Anti-FKBP-1A/FKBP12/FITC |
| 中文名称 | FITC标记的肽基脯氨酰顺反异构酶FKBP12抗体 |
| 别 名 | 12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1; FK506 binding protein 12; FK506 binding protein 1A 12kDa; FK506 binding protein 1A; FK506 binding protein T cell 12 kD; FK506-binding protein 1A; FKB1A_HUMAN; FKBP 12; FKBP 1A; FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP12 Exip3; FKBP12C; FKBP1A; Immunophilin FKBP12; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP1A; PKC12; PKCI2; PPIase; PPIase FKBP1A; Protein kinase C inhibitor 2; Rotamase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FKBP-1A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008] Function: May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Subcellular Location: Cytoplasm. Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain. Database links: Entrez Gene: 2280 Human Entrez Gene: 14225 Mouse Entrez Gene: 25639 Rat Omim: 186945 Human SwissProt: P62942 Human SwissProt: P26883 Mouse SwissProt: Q62658 Rat Unigene: 471933 Human Unigene: 700839 Human Unigene: 278458 Mouse Unigene: 381214 Mouse Unigene: 80611 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白是免疫亲合蛋白家族的成员，在免疫调节和涉及蛋白折叠和转运的基本细胞过程中起作用。蛋白质是顺式反式脯氨酰异构酶，结合免疫抑制剂FK506和雷帕霉素。它与多种细胞内信号转导蛋白（包括Ⅰ型TGF-β受体）相互作用。它还与多种细胞内钙释放通道相互作用，并协调四边形骨骼肌ry.ine受体的多蛋白复合物的形成。在小鼠中，这种同源基因的缺失导致先天性心脏病，称为左心室心肌不致密。多个交替剪接变异体，编码相同的蛋白质，已被鉴定。人类基因组包含五个与该基因相关的假基因，其中至少有一个是转录的。[ RefSeq，SEP 2008提供]