FITC标记的泛素蛋白连接酶J2抗体
产品名称： FITC标记的泛素蛋白连接酶J2抗体
英文名称： Anti-UBE2J2/FITC
产品编号： HZ-8381R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-UBE2J2/FITC Conjugated antibody
FITC标记的泛素蛋白连接酶J2抗体
| 产品编号 | bs-8381R-FITC |
| 英文名称 | Anti-UBE2J2/FITC |
| 中文名称 | FITC标记的泛素蛋白连接酶J2抗体 |
| 别 名 | NCUBE-2; NCUBE2; Non-canonical ubiquitin-conjugating enzyme 2; UB2J2_HUMAN; UBC6; UBC6 homolog; ube2j2; Ubiquitin-conjugating enzyme E2 J2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBE2J2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ubiquitination is an important molecular mechanism by which abnormal or short-lived proteins are targeted for degradation by the concerted efforts of at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2J2 (Ubiquitin-conjugating enzyme E2 J2), also known as NCUBE2 (Non-canonical ubiquitin-conjugating enzyme 2), is a 259 amino acid single pass type IV membrane protein that that belongs to the E2 ubiquitin-conjugating enzyme family and is involved in protein degradation. Localized to the membrane of the endoplasmic reticulum (ER), UBE2J2 catalyzes the attachment of ubiquitin to misfolded membrane proteins, thereby targeting them for proteasomal destruction. This ATP-dependent reaction yields AMP, a diphosphate and a ubiquitin-tagged protein and may be a method of quality control within the ER. Two isoforms of UBE2J2 exist due to alternative splicing events. Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). Subcellular Location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Similarity: Belongs to the ubiquitin-conjugating enzyme family. Database links: Entrez Gene: 118424 Human Entrez Gene: 140499 Mouse Entrez Gene: 298689 Rat SwissProt: Q2TA03 Cow SwissProt: Q8N2K1 Human SwissProt: Q6P073 Mouse Unigene: 191987 Human Unigene: 371673 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
泛素化是一种重要的分子机制，通过至少三类酶：泛素激活酶（E1S）、泛素缀合酶（E2S）和泛素蛋白连接酶（E3S）的协同作用，使异常或短命的蛋白质被靶向降解。UBE2J2（泛素缀合酶E2 J2），也称NCuBE2（非经典泛素缀合酶2），是一种259氨基酸单程型IV膜蛋白，属于E2泛素缀合酶家族，参与蛋白质降解。定位于内质网（ER）的膜上，UBE2J2催化泛素附着到错误折叠的膜蛋白，从而针对蛋白酶体破坏。这种ATP依赖的反应产生AMP、二磷酸和泛素标记蛋白，并且可以是ER内的质量控制的方法。UBE2J2的两种异构体由于选择性剪接事件而存在。