RAN (Human) Recombinant Protein (P02)
产品名称： RAN (Human) Recombinant Protein (P02)
英文名称： RAN (Human) Recombinant Protein (P02)
产品编号： H00005901-P02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human RAN full-length ORF ( AAH14901.1, 1 a.a. - 216 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
- Theoretical MW (kDa):
- 49.5
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 5901
- GeneBank Accession#:
- BC014901
- Protein Accession#:
- AAH14901.1
- Gene Name:
- RAN
- Gene Alias:
- ARA24,Gsp1,TC4
- Gene Description:
- RAN, member RAS oncogene family
- Omim ID:
- 601179
- Gene Ontology:
- Hyperlink
- Gene Summary:
- RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq
- Other Designations:
- OK/SW-cl.81,RanGTPase,guanosine triphosphatase Ran,member RAS oncogene family,ras-related nuclear protein
- Related Disease
- Adenocarcinoma
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Esophageal Neoplasms
- Fetal Membranes, Premature Rupture
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Kidney Neoplasms
- Lung Neoplasms
- Mouth Neoplasms
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Precancerous Conditions
- Premature Birth