FITC标记的HOMER3蛋白抗体
产品名称： FITC标记的HOMER3蛋白抗体
英文名称： Anti-HOMER3/FITC
产品编号： HZ-5391R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-HOMER3/FITC Conjugated antibody
FITC标记的HOMER3蛋白抗体
| 英文名称 | Anti-HOMER3/FITC |
| 中文名称 | FITC标记的HOMER3蛋白抗体 |
| 别 名 | HOMER 3; Homer 3D protein; Homer homolog 3 (Drosophila); Homer neuronal immediate early gene 3; Homer protein homolog 3; Homer3; VESL3; HOME3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOMER3 (51-250aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-termina coiled-coil domain and two leucine zipper motifs that are involved l in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Subunit: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. Subcellular Location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. Similarity: Belongs to the Homer family. Contains 1 WH1 domain. Database links: UniProtKB/Swiss-Prot: Q9NSC5.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码HOMER家族的突触后密度支架蛋白的成员，其具有类似的结构域结构，其由N-末端激活/血管扩张刺激磷蛋白同源1结构域介导蛋白质-蛋白质相互作用，羧基末端卷曲COI。L域和两个亮氨酸拉链基序参与L的自寡聚反应。编码的蛋白质结合了许多其他蛋白质，包括Ⅰ型代谢型谷氨酸受体、肌醇1，4，5三磷酸受体和淀粉样前体蛋白，并参与了多种生物学功能，如神经元信号传导、T细胞活化和淀粉样蛋白运输。Dβ肽。选择性剪接导致多个转录变体。