Thrombopoietin(TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.   
Recombinant mouse TPO produced in HEK293 cells with C-terminal Histidine tag, is a polypeptide chain containing 341 amino acids. rmTPO has a molecular mass of 62~70 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at ExCell Bio.