FITC标记的转录辅助因子退变样蛋白4抗体
产品名称： FITC标记的转录辅助因子退变样蛋白4抗体
英文名称： Anti-VGLL4/FITC
产品编号： HZ-9185R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-VGLL4/FITC Conjugated antibody
FITC标记的转录辅助因子退变样蛋白4抗体
| 产品编号 | bs-9185R-FITC |
| 英文名称 | Anti-VGLL4/FITC |
| 中文名称 | FITC标记的转录辅助因子退变样蛋白4抗体 |
| 别 名 | Transcription cofactor vestigial like protein 4; Vestigial like protein 4; VGL 4; VGLL4; VGLL4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VGLL4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-4 (vestigial-like protein 4) is a 290 amino acid nuclear protein that interacts with TEF-1 and MEF-2. Vgl-4 is the only member of the vestigial-like family that is expressed in heart. Overexpression of Vgl-4 in cardiac myocytes interferes with basal expression and ?-adrenergic receptor-dependent activation of a TEF-1 dependent skeletal ?actin promoter. This suggests that Vgl-4 counteracts ?-adrenergic activation of gene expression in cardiomyocytes. There are two isoforms of Vgl-4 that are produced as a result of alternative splicing events. Function: May act as a specific coactivator for the mammalian TEFs (By similarity). Subunit: Interacts with TEFs (By similarity). Interacts with IRF2BP2. Subcellular Location: Nuclear Similarity: Belongs to the vestigial family. Database links: Entrez Gene: 9686 Human Entrez Gene: 232334 Mouse Entrez Gene: 297523 Rat SwissProt: Q14135 Human SwissProt: Q80V24 Mouse Unigene: 23131 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转录增强因子-1（TEF-1）家族转录因子调节肌肉和胎盘组织特异性基因表达。TEF-1赋予组织特异性的机制在很大程度上取决于TEF-1与组织特异性辅因子的相互作用。转录辅因子VGL-4（残遗样蛋白4）是与TEF-1和MEF-2相互作用的290氨基酸核蛋白。VGL－4是在心脏中表达的遗迹样家族的唯一成员。VGL－4在心肌细胞中的过度表达干扰了基础表达和？肾上腺素能受体依赖性激活的依赖于TEF-1的骨骼？肌动蛋白启动子这表明VGL-4抵消了？心肌细胞基因表达的肾上腺素能激活。有两种异构形式的VGL - 4，这是由于选择性剪接事件产生的。