分子量：Calculated MW: 37kDa/133kDa/135kDa/137kDa/140kDa/141kDa
Observed MW: 150KDa

细胞定位：Cytoplasm

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.