CD41/血小板膜糖蛋白Ⅱb单克隆抗体-抗体-抗体-生物在线
上海沪震实业有限公司
CD41/血小板膜糖蛋白Ⅱb单克隆抗体

CD41/血小板膜糖蛋白Ⅱb单克隆抗体

商家询价

产品名称: CD41/血小板膜糖蛋白Ⅱb单克隆抗体

英文名称: CD41/Integrin alpha 2b

产品编号: hzm-33112M

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500

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 Mouse Anti-CD41/Integrin alpha 2b antibody

 

产品编号 hzm-33112M
英文名称 CD41/Integrin alpha 2b
中文名称 CD41/血小板膜糖蛋白Ⅱb单克隆抗体
别    名 platelet glycoprotein IIb of IIb/IIIa complex; Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; GPIIb; GTA; HPA3; CD 41; CD41; CD41 antigen; CD41a; CD41b; GP2b; GPalpha IIb; GPalphaIIb; Integrin alpha IIb; Integrin alpha IIb precursor; ITGA 2B; ITGA2B; ITGAB; Platelet fibrinogen receptor alpha; Platelet fibrinogen receptor alpha subunit; Platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet specific antigen bak; ITA2B_HUMAN.  
   
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞粘附分子  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 9B10
交叉反应 Human, 
产品应用 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD41/Integrin alpha 2b: 
亚    型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. 

Function:
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. 

Subcellular Location:
Membrane. 

DISEASE:
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. 

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.

SWISS:
P08514

Gene ID:
3674

Database links:

Entrez Gene: 3674 Human

Entrez Gene: 16399 Mouse

Entrez Gene: 685269 Rat

Omim: 607759 Human

SwissProt: P08514 Human

SwissProt: Q9QUM0 Mouse

Unigene: 411312 Human

Unigene: 26646 Mouse

Unigene: 128177 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications