FITC标记的AN1型锌指蛋白5抗体
产品名称： FITC标记的AN1型锌指蛋白5抗体
英文名称： Anti-ZFAND5/FITC
产品编号： HZ-10142R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZFAND5/FITC Conjugated antibody
FITC标记的AN1型锌指蛋白5抗体
| 英文名称 | Anti-ZFAND5/FITC |
| 中文名称 | FITC标记的AN1型锌指蛋白5抗体 |
| 别 名 | AN1-type zinc finger protein 5; ZA20D2; ZFAN5_HUMAN; Zfand5; ZFAND5A; zinc finger A20 domain containing 2; Zinc finger A20 domain containing protein 2; Zinc finger A20 domain-containing protein 2; zinc finger AN1 type domain 5; Zinc finger protein 216; ZNF216. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 信号转导 细胞凋亡 转录调节因子 细胞外基质 表观遗传学 |
| 抗体来源 | Rabbita |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZFAND5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Could be involved in regulating NF-kappa-B activation and apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Involved in protein degradation via the ubiquitin-proteasome system and plays a critical role in muscle atrophy. May act by anchoring ubiquitinylated proteins to the proteasome, playing a critical role in protein degradation. Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Subunit: Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain). Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). Similarity: Contains 1 A20-type zinc finger. Contains 1 AN1-type zinc finger. Database links: Entrez Gene: 7763 Human Entrez Gene: 22682 Mouse Entrez Gene: 293960 Rat Omim: 604761 Human SwissProt: O76080 Human SwissProt: O88878 Mouse SwissProt: B5DF11 Rat Unigene: 406096 Human Unigene: 292405 Mouse Unigene: 379919 Mouse Unigene: 4050 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
抑制过表达RIPK1和TRAF6而不是RelA引起的NF-κB激活。抑制肿瘤坏死（TNF）、IL-1和TLR4以剂量依赖的方式诱导NF-KAPPA-B活化。过度表达使细胞对TNF诱导的细胞凋亡敏感。可能参与调节NF-κB活化和凋亡。是破骨细胞分化的有效抑制因子。通过泛素蛋白酶体系统参与蛋白质降解，在肌肉萎缩中起关键作用。可能通过锚定泛素化蛋白到蛋白酶体，在蛋白质降解中起关键作用。