FITC标记的环指蛋白165抗体
产品名称： FITC标记的环指蛋白165抗体
英文名称： Anti-RNF165/FITC
产品编号： HZ-9258R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RNF165/FITC Conjugated antibody
FITC标记的环指蛋白165抗体
| 产品编号 | bs-9258R-FITC |
| 英文名称 | Anti-RNF165/FITC |
| 中文名称 | FITC标记的环指蛋白165抗体 |
| 别 名 | ring finger protein 165; RN165_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF165 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in protein-protein interactions and protein-DNA interactions. Specifically, they are thought to be involved in the ubiquitination pathway of protein degradation. RNF165 (RING finger protein 165) is a 346 amino acid protein that contains one RING-type zinc finger. Via its RING-type zinc finger, RNF165 may play a role in transcriptional regulation and protein degradation events. The gene encoding RNF165 maps to human chromosome 18, which houses over 300 genes, including Trisomy 18, or Edwards syndrome, the second most common trisomy after Downs syndrome. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are also associated with chromosome 18. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 494470 Human Entrez Gene: 225743 Mouse Entrez Gene: 307251 Rat SwissProt: Q6ZSG1 Human SwissProt: E9QAU8 Mouse Unigene: 501114 Human Unigene: 23293 Mouse Unigene: 44903 Rat Important Note: |
环型锌指基序存在于许多病毒和真核蛋白质中，并且由能够结合两个锌原子的保守的富含半胱氨酸的结构域构成。含有保守结构域的蛋白质通常参与蛋白质-蛋白质相互作用和蛋白质- DNA相互作用。特别地，它们被认为参与了蛋白质降解的泛素化途径。RNF165（环指蛋白165）是含有一个环状锌指的346氨基酸蛋白质。RNF165可通过其环状锌指蛋白在转录调控和蛋白降解事件中发挥作用。编码RNF165的基因映射到人类第18号染色体，其包含300个基因，包括18号染色体三体，或爱德华兹综合征，第二个最常见的唐氏综合征三体综合征。染色体18和14之间的易位是癌症中最常见的易位，并发生在滤泡性淋巴瘤中。尼曼匹克病、遗传性出血性毛细血管扩张症和红细胞生成性原卟啉症也与第18号染色体有关。