常规信息

• 别名
  • Acetate kinase 1
  • Acetokinase 1
  • ACK

  • ACK 1
  • ACK-1
  • ACK1
  • ACK1_HUMAN
  • Activated Cdc42 associated kinase 1
  • Activated CDC42 kinase 1
  • Activated p21cdc42Hs kinase
  • FLJ44758
  • FLJ45547
  • p21cdc42Hs
  • TNK 2
  • TNK2
  • Tyrosine kinase non receptor 2
  • Tyrosine kinase non receptor protein 2
  • Tyrosine kinase non-receptor protein 2

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• 功能Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on Tyr-176 resulting in its activation. Phosphorylates AR on Tyr-267 and Tyr-363 and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on Tyr-287. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
• 组织特异性The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.
• 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
  Contains 1 CRIB domain.
  Contains 1 protein kinase domain.
  Contains 1 SH3 domain.
  Contains 1 UBA domain.
• 结构域The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
  The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation.
  The UBA domain binds both poly- and mono-ubiquitin.
• 翻译后修饰Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC.
  Ubiquitinated by NEDD4. Its EGF-induced degradation is EGFR activation-dependent and is processed by lysosomes, not proteasomes.
• 细胞定位Cell membrane. Nucleus. Endosome. Cell junction > adherens junction. Cytoplasmic vesicle membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes.
• Information by UniProt