HLA-DRB4 (Human) Recombinant Protein (P01)
产品名称: HLA-DRB4 (Human) Recombinant Protein (P01)
英文名称: HLA-DRB4 (Human) Recombinant Protein (P01)
产品编号: H00003126-P01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human HLA-DRB4 full-length ORF ( AAH05312, 30 a.a. - 266 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- GDTQPRFLEQAKCECRFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS
- Theoretical MW (kDa):
- 51.81
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 3126
- GeneBank Accession#:
- BC005312
- Protein Accession#:
- AAH05312
- Gene Name:
- HLA-DRB4
- Gene Alias:
- DRB4,HLA-DR4B
- Gene Description:
- major histocompatibility complex, class II, DR beta 4
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
- Other Designations:
- DRB1 transplantation antigen,HLA DRB1*1202,MHC HLA DR-beta chain,MHC class II HLA-DR-beta-7,MHC class II antigen HLA-DR-beta,MHC class II antigen HLA-DRB1,MHC class2 antigen,class II histocompatibility antigen HLA DR alpha, beta1-0307,human leucocyte anti
- Related Disease
- Abortion, Habitual
- Abruptio Placentae
- Alveolar Bone Loss
- Aortic Aneurysm, Abdominal
- Asthma
- Bronchiolitis
- Cataplexy
- Churg-Strauss Syndrome
- Colitis, Ulcerative
- Dementia
- Disease Susceptibility
- Genetic Predisposition to Disease
- Gingival Hemorrhage
- Graft vs Host Disease
- Hallucinations
- Hepatitis, Autoimmune
- HIV Infections
- Inflammation
- Latex Hypersensitivity