FITC标记的磷酸化内收蛋白a1抗体
产品名称： FITC标记的磷酸化内收蛋白a1抗体
英文名称： Anti-phospho-alpha Adducin(Ser436)/FITC
产品编号： HZ-15968R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-alpha Adducin(Ser436)/FITC Conjugated antibody
FITC标记的磷酸化内收蛋白a1抗体
| 英文名称 | Anti-phospho-alpha Adducin(Ser436)/FITC |
| 中文名称 | FITC标记的磷酸化内收蛋白a1抗体 |
| 别 名 | alpha Adducin(phospho S436); alpha Adducin(phospho Ser436); p-alpha Adducin(S436); p-alpha Adducin(Ser436); ADD 1; ADD A; ADD1; ADD1 protein; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Adducin 1 alpha; Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte hosphor subunit alpha; Erythrocyte adducin subunit alpha. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Ser436 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Subunit: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. Similarity: Belongs to the aldolase class II family. Adducin subfamily. Database links: Entrez Gene: 118 Human Entrez Gene: 11518 Mouse Entrez Gene: 24170 Rat Omim: 102680 Human SwissProt: P35611 Human SwissProt: Q9QYC0 Mouse SwissProt: Q63028 Rat Unigene: 183706 Human Unigene: 289106 Mouse Unigene: 5788 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
内收蛋白是由三个基因（α，β，γ）编码的细胞骨架蛋白家族。Adducin是与质膜内小叶相关的蛋白质，是位于膜骨架的光谱-肌动蛋白连接处的蛋白质之一。在细胞凋亡过程中，皮质肌动蛋白细胞骨架网络丢失，而Adducin在皮质肌动蛋白网络组织中处于中心地位。Adducin Alpha是参与肾小管钠泵活性的细胞骨架蛋白，与高血压相关。内收蛋白α和Adducin Gamma的表达普遍存在于内含β-内含肽的限制性表达。人脑和骨髓等造血组织和小鼠脾脏中高水平表达Adducinβ。