FITC标记的FAM18B蛋白抗体
产品名称： FITC标记的FAM18B蛋白抗体
英文名称： Anti-FAM18B/FITC
产品编号： HZ-14768R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FAM18B/FITC Conjugated antibody
FITC标记的FAM18B蛋白抗体
| 英文名称 | Anti-FAM18B/FITC |
| 中文名称 | FITC标记的FAM18B蛋白抗体 |
| 别 名 | CGI 148; F18B1_HUMAN; Fam18b1; Family with sequence similarity 18, member B; Hypothetical protein LOC51030; Hypothetical protein LOC67510; NPD008; Ortholog of human family with sequence similarity 18 member B FAM18B; Protein FAM18B1; RP23 428I5.3; YDR084C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, ,Danio rerio |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM18B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FAM18B2 is a 276 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding FAM18B2 maps to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. Subcellular Location: Membrane. Similarity: Belongs to the FAM18/TVP23 family. Database links: Entrez Gene: 51030 Human SwissProt: Q9NYZ1 Human Unigene: 87295 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FAM18B2是一种276氨基酸多通道膜蛋白，以两种交替剪接的异构体存在。编码FAM18B2的基因定位于人类17号染色体，占人类基因组的2.5%以上，约8100万个碱基编码1200多个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。肿瘤抑制因子p53通过DNA修复和细胞死亡来调节细胞命运，从而维持细胞遗传完整性。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。和p53一样，BRCA1直接参与DNA修复，尽管它特别被认为是早期发病的乳腺癌和易患卵巢、结肠、前列腺和输卵管癌的遗传决定因素。染色体17还与神经纤维瘤病有关，神经纤维瘤病以神经和表皮病变为特征，雪旺细胞生长失调。亚力山大病、Bito-Hog Dube综合征和Cavava病也与17号染色体有关。