重组人细胞周期蛋白依赖型激酶2(CDK2)

中文名称：重组人细胞周期蛋白依赖型激酶2(CDK2)
英文名称：Recombinant Human Cyclin-Dependent Kinase 2
产品规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu298在N端含有His标签。

CDK2质量控制：＞95%(还原性SDS-PAGE)

CDK2制剂：液体

CDK2保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于CDK2：
Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells. 

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