Olr1 (NM_138648) Mouse Recombinant Protein
产品名称: Olr1 (NM_138648) Mouse Recombinant Protein
英文名称: Olr1 (NM_138648) Mouse Recombinant Protein
产品编号: PM42550M5
产品价格: 0
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: null
安诺伦(北京)生物科技有限公司
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产品概述:Purified recombinant protein of Mouse oxidized low density lipoprotein (lectin-like) receptor 1 (Olr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM55536V], encoding Mouse full-length Olr1. 表达系统:HEK293T 种属:Mouse 标签类型:C-MYC/DDK 分子量:42.1 kDa 通用名:Olr1 总结:Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).[UniProtKB/Swiss-Prot Function] 形式:Liquid 浓度:>50 ug/mL as determined by microplate BCA method 纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. 别名:LOX-1; Scare1; SR-EI