FITC标记的GalNAc-T5蛋白抗体
产品名称： FITC标记的GalNAc-T5蛋白抗体
英文名称： Anti-GALNT5/FITC
产品编号： HZ-16221R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GALNT5/FITC Conjugated antibody
FITC标记的GalNAc-T5蛋白抗体
| 英文名称 | Anti-GALNT5/FITC |
| 中文名称 | FITC标记的GalNAc-T5蛋白抗体 |
| 别 名 | GALNAC T5; N acetylgalactosaminyltransferase; Polypeptide GalNAc transferase 5; polypeptide N -acetylgalactosaminyltransferase 5; pp GaNTase 5; Protein UDP acetylgalactosaminyltransferase 5; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 5; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 106kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GALNT5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T5 (Polypeptide N-acetylgalactosaminyltransferase 5), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5, is a 940 amino acid protein that displays enzymatic activity toward EA2 peptide substrate with weaker activity toward Muc2 or Muc 1b substrates. Its N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. EXT2 directly interacts with GalNAc-T5, suggesting that these proteins may corroborate in glycosaminoglycan synthesis. Function: GALNT5 can catalyze the initial reaction in O-linked oligosaccharide biosynthesis,the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT5 has activity toward EA2 peptide substrate, but it has a weak activity toward Muc2 or Muc1b substrates. Subunit: Interacts with EXT2. Does not interact with EXT1, EXTL1 or EXTL3. Subcellular Location: Cell Membrane and Golgi Apparatus Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain. Database links: Entrez Gene: 11227 Human Entrez Gene: 241391 Mouse Entrez Gene: 83627 Rat SwissProt: Q7Z7M9 Human SwissProt: Q8C102 Mouse SwissProt: O88422 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UDP-N-乙酰-α-D-半乳糖胺:多肽N-乙酰半乳糖胺基转移酶(GalNAc-T)家族是底物特异性蛋白，催化GalNAc(N-乙酰半乳糖胺)向丝氨酸和苏氨酸残基转移至各种蛋白质上，从而引发粘蛋白型O链。高尔基体中的ED糖基化。GalNAc-T5(多肽N-乙酰半乳糖胺基转移酶5)又称UDP-GalNAc：多肽N-乙酰半乳糖胺基转移酶5，是一种940氨基酸蛋白，对EA2肽底物显示酶活性，对Muc2或Muc 1b底物显示较弱的活性。其N端结构域参与底物结合和锰配位，而C端结构域参与UDP-Gal结合和催化反应。Ext2直接与GalNC-T5相互作用，提示这些蛋白可在糖胺聚糖合成中确证。