重组人甘氨酸N-甲基转移酶(GNMT)

中文名称：重组人甘氨酸N-甲基转移酶(GNMT)
英文名称：Recombinant Human Glycine N-Methyltransferase
产品规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Asg294在N端含有His标签。

GNMT质量控制：＞95%(还原性SDS-PAGE)

GNMT制剂：液体

GNMT保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于GNMT：
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. 

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