GP1BB (Human) Recombinant Protein
产品名称： GP1BB (Human) Recombinant Protein
英文名称： GP1BB (Human) Recombinant Protein
产品编号： H00002812-G01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human GP1BB full-length ORF (AAI60146.1) recombinant protein without tag.
- Sequence:
- MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSCAGTLVDCGRRGLTWASLPTAFPVDTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAEDELRAACAPGPLCWGALAAQLALLGLGLLHALLLVLLLCRLRRLRARARARAAARLSLTDPLVAERAGTDES
- Theoretical MW (kDa):
- 22.7
- Form:
- Liquid
- Preparation Method:
- in vitro wheat germ expression system with proprietary liposome technology
- Storage Buffer:
- 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Note:
- Best use within three months from the date of receipt of this protein.
- Publication Reference
- 1.
- Production and partial purification of membrane proteins using a liposome-supplemented wheat cell-free translation system.
Nozawa A, Ogasawara T, Matsunaga S, Iwasaki T, Sawasaki T, Endo Y. BMC Biotechnol. 2011 Apr 11;11:35.
- Application Image
- Antibody Production
- Functional Study
- Compound Screening
- Entrez GeneID:
- 2812
- GeneBank Accession#:
- BC160146.1
- Protein Accession#:
- AAI60146.1
- Gene Name:
- GP1BB
- Gene Alias:
- CD42c
- Gene Description:
- glycoprotein Ib (platelet), beta polypeptide
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene. [provided by RefSeq
- Other Designations:
- glycoprotein Ib, beta polypeptide,nuclear localization signal deleted in velocardiofacial syndrome
- Gene Pathway