Rat MAb to KSHV/HHV-8 ORF 73 (LNA-1)
产品名称： Rat MAb to KSHV/HHV-8 ORF 73 (LNA-1)
英文名称： Rat MAb to KSHV/HHV-8 ORF 73 (LNA-1)
产品编号： Rat MAb to KSHV/HHV-8 ORF 73 (LNA-1)
产品价格： 0
产品产地： 美国
品牌商标：
更新时间： 2023-09-19T20:51:30
使用范围： null
Description(名称）
Rat MAb to KSHV/HHV-8 ORF 73 (LNA-1)
Catalog #（货号）
13-210-100
Size（规格）
100 µg
Price（价格）
请联系：0769-2289-0558， 0769-22890598， QQ:2533190771
Rat monoclonal antibody to latent nuclear antigen (LNA-1) encoded by ORF 73 of Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8. This antibody originates from ascites fluid and is purified by protein G chromatography.
For research use only. Not for use in diagnostic procedures.
Details（注意事项）:
Shipping and Storage: This product is shipped frozen on dry ice. Store at -20°C upon receipt. Avoid multiple freeze-thaw cycles as product degradation may result.
Recommendations: Upon thawing, centrifuge the vial for a few seconds to remove residual droplets from the lid.
Safe Handling Recommendation: This biological preparation should be handled in accordance with biosafety guidelines defined in the BMBL, NIH-CDC HHS Publication No. 93-8395.
FAQ（常见问题）:
How are ABI’s Antibodies supplied? All ABI antibodies are supplied frozen.
How should I store ABI’s Antibodies? We recommend that all antibodies be aliquoted into single-use size portions and stored frozen at -20° C or below. Avoid multiple freeze-thaw cycles as this will affect antibody activity. Do not dilute and freeze – make final dilution just prior to use.
Will ABI’s Antibodies work in Western blot? Not all ABI antibodies work in Western blot. Please see the Certificate of Analysis for each antibody to determine its suitability for Western blot use.
Applications for use（适用范围）:
- ELISA
- Western blot
- Dot blot
- IFA
- Other Protein-Based Assays
- IHC/ICC
- Flow Cytometry
- Antigen Detection
Quality control testing includes（质量控制检测包括）:
- IFA
- SDS-PAGE
- Protein Concentration
Certificate of Analysis（分析报告）:
Reference Articles（已发表参考文献）:
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Myoung J, Ganem D. “Infection of Lymphoblastoid Cell Lines by Kaposi’s Sarcoma-Associated Herpesvirus: Critical Role of Cell-Associated Virus.” J. Virol.. 2011;85(19):9767-77.
Alkharsah KR, Singh VV, Bosco R, et al. “Deletion of Kaposi’s Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells.” J. Virol.. 2011;85(19):10375-88.
Chen W, Hilton IB, Staudt MR, Burd CE, Dittmer DP. “Distinct p53, p53:LANA, and LANA Complexes in Kaposi’s Sarcoma-Associated Herpesvirus Lymphomas.” Journal of Virology. 2010;84(8):3898-3908.
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Ohsaki E, Suzuki T, Karayama M, Ueda K. “Accumulation of LANA at nuclear matrix fraction is important for Kaposi’s sarcoma-associated herpesvirus replication in latency.” Virus Research. 2009;139(1):74-84.
Mejía AF, Gierbolini L, Jacob B, Westmoreland SV. “Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta).” Journal of Medical Primatology. 2009;38(2):121-124.
Kuang E, Wu F, Zhu F. “Mechanism of Sustained Activation of Ribosomal S6 Kinase (RSK) and ERK by Kaposi Sarcoma-associated Herpesvirus ORF45: Multiprotein Complexes Retain Active Phosphorylated ERK and RSK and Protect Them From Dephosphorylation.” Journal of Biological Chemistry. 2009;284(20):13958-13968.
Kelley-Clarke B, De Leon-Vazquez E, Slain K, Barbera AJ, Kaye KM. “Role of Kaposi’s Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence.” Journal of Virology. 2009;83(9):4326-4337.
Li X, Zhu F. “Identification of the Nuclear Export and Adjacent Nuclear Localization Signals for ORF45 of Kaposi’s Sarcoma-Associated Herpesvirus.” Journal of Virology. 2009;83(6):2531-2539.
Laurent C, Do C, Gascoyne RD, et al. “Anaplastic Lymphoma Kinase-Positive Diffuse Large B-Cell Lymphoma: A Rare Clinicopathologic Entity With Poor Prognosis.” Journal of Clinical Oncology. 2009;27(25):4211-4216.
Tsibris A M N, Paredes R, Chadburn A, et al. “Lymphoma Diagnosis and Plasma Epstein?Barr Virus Load during Vicriviroc Therapy: Results of the AIDS Clinical Trials Group A5211.” Clinical Infectious Diseases. 2009;48(5):642-649.
Chen D, Sandford G, Nicholas J. “Intracellular Signaling Mechanisms and Activities of Human Herpesvirus 8 Interleukin-6.” Journal of Virology. 2009;83(2):722-733.
Chang H, Wachtman LM, Pearson CB, et al. “Non-Human Primate Model of Kaposi’s Sarcoma-Associated Herpesvirus Infection.” PLoS Pathogens. 2009;5(10):e1000606. Abstract
Sivakumar R, Sharma-Walia N, Raghu H, et al. “Kaposi’s Sarcoma-Associated Herpesvirus Induces Sustained Levels of Vascular Endothelial Growth Factors A and C Early during In Vitro Infection of Human Microvascular Dermal Endothelial Cells: Biological Implications.” Journal of Virology. 2008;82(4).
Rappocciolo G, Hensler HR, Jais M, et al. “Human Herpesvirus 8 Infects and Replicates in Primary Cultures of Activated B Lymphocytes through DC-SIGN.” J. Virol.. 2008;82:4793-4806. Abstract
Bartolo DDL, Cannon M, Liu Y-F, et al. “KSHV LANA inhibits TGF-2 signaling through epigenetic silencing of the TGF-2 type II receptor.” Blood. 2008;111(9).
Yang Z, Yan Z, Wood C. “Kaposi’s Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication.” Journal of Virology. 2008;82(7).
Garrigues JH, Rubinchikova YE, DiPersio MC, Rose TM. “Integrin alpha-V beta 3 Binds to the RGD Motif of Glycoprotein B of Kaposi’s Sarcoma-Associated Herpesvirus and Functions as an RGD-Dependent Entry Receptor.” Journal of Virology. 2008;82(3).
Kuang E, Tang Q, Maul GG, Zhu F. “Activation of p90 Ribosomal S6 Kinase by ORF45 of Kaposi’s Sarcoma-Associated Herpesvirus and Its Role in Viral Lytic Replication.” Journal of Virology. 2008;82(4).
Morris VA, Punjabi AS, Lagunoff M. “Activation of Akt through gp130 Receptor Signaling Is Required for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Lymphatic Reprogramming of Endothelial Cells.” Journal of Virology. 2008;82(17).
Garrigues HJ, Rubinchikova YE, DiPersio CM, Rose TM. “Integrin V 3 Binds to the RGD Motif of Glycoprotein B of Kaposi’s Sarcoma-Associated Herpesvirus and Functions as an RGD-Dependent Entry Receptor.” Journal of Virology. 2008;82(3):1570-1580.
Yang Z, Wood C. “The Transcriptional Repressor K-RBP Modulates RTA-Mediated Transactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus.” Journal of Virology. 2007;81(12):6294-6306.
Watanabe A, Higuchi M, Fukushi M, et al. “A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences.” Virus Genes. 2007;34(2):127-136.
Engels E, Mbulaiteye S, Othieno E, et al. “Kaposi sarcoma-associated herpesvirus in non-Hodgkin lymphoma and reactive lymphadenopathy in Uganda.” Human Pathology. 2007;38(2):308-314.
Nun TK, Kroll DJ, Oberlies NH, et al. “Development of a fluorescence-based assay to screen antiviral drugs against Kaposi’s sarcoma associated herpesvirus.” Molecular Cancer Therapeutics. 2007;6(8):2360-2370.
Vart RJ, Nikitenko LL, Lagos D, et al. “Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Interleukin-6 and G-Protein-Coupled Receptor Regulate Angiopoietin-2 Expression in Lymphatic Endothelial Cells.” Cancer Research. 2007;67(9):4042-4051.
Liu J, Martin H, Shamay M, Woodard C, Tang Q-Q, Hayward SD. “Kaposi’s Sarcoma-Associated Herpesvirus LANA Protein Downregulates Nuclear Glycogen Synthase Kinase 3 Activity and Consequently Blocks Differentiation.” Journal of Virology. 2007;81(9):4722-4731.
“Persistent Activation of STAT3 by Latent Kaposi’s Sarcoma-Associated Herpesvirus Infection of Endothelial Cells.” Journal of Virology. 2007;81(5).
Majerciak V, Pripuzova N, McCoy PJ, Gao S-J, Zheng Z-M. “Targeted Disruption of Kaposi’s Sarcoma-Associated Herpesvirus ORF57 in the Viral Genome Is Detrimental for the Expression of ORF59, K8-alpha, and K8.1 and the Production of Infectious Virus.” Journal of Virology. 2007;81(3).
You J, Srinivasan V, Denis GV, et al. “Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes.” Journal of Virology. 2006;80(18):8909-8919.
Murakami Y, Yamagoe S, Noguchi K, et al. “Ets-1-dependent Expression of Vascular Endothelial Growth Factor Receptors Is Activated by Latency-associated Nuclear Antigen of Kaposi’s Sarcoma-associated Herpesvirus through Interaction with Daxx.” J Biol Chem. 2006;281(38).
Fujimuro M, Inoue H, Teishikata Y, Ishida Y, Yokosawa H. “Apoptotic Effect of Ganciclovir on Primary Effusion Lymphoma Cells Infected with Kaposi’s Sarcoma-Associated Herpesvirus.” Nucleosides, Nucleotides & Nucleic Acids. 2006;25(4-6):635-645.
Carroll PA, Kenerson HL, Yeung RS, Lagunoff M. “Latent Kaposi’s Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Activates Hypoxia-Induced Factors.” Journal of Virology. 2006;80(21).
Fujimuro M, Liu J, Zhu J, Yokosawa H, Hayward SD. “Regulation of the Interaction between Glycogen Synthase Kinase 3 and the Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen.” Journal of Virology. 2005;79(16):10429-10441.
Deloose STP, Smit LA, Pals FT, Kersten M-J, van Noesel CJM, Pals ST. “High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma.” Leukemia. 2005;19(5):851-855.
Pantanowitz L, Dorfman R, Tahan S, Schwartz E, Dezube B, Kohler S. “C-Kit (CD117) Expression in AIDS-Related, Classic, and African Endemic Kaposi Sarcoma.” Applied Immunohistochemistry & Molecular Morphology. 2005;13(2):162-166.
Carbone A, Gaidano G, Tirelli U, Gloghini A, Vaccher E, Marchetti G. “KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype.” Journal of Clinical Pathology. 2005;58(10):1039-1045.
Ramirez JA, Laskin WB, Guitart J. “Lymphangioma-like Kaposi sarcoma.” Journal of Cutaneous Pathology. 2005;32(4):286-292.
Krug LT, Pozharskaya VP, Yu Y, Inoue N, Offermann MK. “Inhibition of Infection and Replication of Human Herpesvirus 8 in Microvascular Endothelial Cells by Alpha Interferon and Phosphonoformic Acid.” Journal of Virology. 2004;78(15):8359-8371.
Osawa H, Kaneko Y, Mutoh H, et al. “Aberrant Expression of CDX2 in the Metaplastic Epithelium and Inflammatory Mucosa of the Gallbladder.” The American Journal of Surgical Pathology. 2004;28(9):1253-1254.
Sakakibara S, UEDA K, Nishimura K, et al. “Accumulation of Heterochromatin Components on the Terminal Repeat Sequence of Kaposi’s Sarcoma-Associated Herpesvirus Mediated by the Latency-Associated Nuclear Antigen.” Journal of Virology. 2004;78(14):7299-7310.
Pozharskaya VP, Weakland LL, Zimring JC, et al. “Short Duration of Elevated vIRF-1 Expression during Lytic Replication of Human Herpesvirus 8 Limits Its Ability To Block Antiviral Responses Induced by Alpha Interferon in BCBL-1 Cells.” Journal of Virology. 2004;78(12).
Robin Y-M, Guillou L, Michels J-J, Coindre J-M. “Human Herpesvirus 8 Immunostaining: A Sensitive and Specific Method for Diagnosing Kaposi Sarcoma in Paraffin-Embedded Sections.” American Journal of Clinical Pathology. 2004;121(3).
Blasius A, Vermi W, Krug A, Facchetti F, Cella M, Colonna M. “A cell-surface molecule selectively expressed on murine natural interferon–producing cells that blocks secretion of interferon-alpha.” Blood. 2004;103(11).
Patel RM, Goldblum JR, Hsi ED. “Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma.” Modern Pathology. 2004;17.
Aoki Y, Tosato G. “HIV-1 Tat enhances Kaposi sarcoma–associated herpesvirus (KSHV) infectivity.” Blood. 2004;104(3).
Du M-Q, Diss TC, Liu H, et al. “KSHV- and EBV-associated germinotropic lymphoproliferative disorder.” Blood. 2002;100(9).
Webster-Cyriaque J. “Development of Kaposi’s Sarcoma in a Surgical Wound.” The New England Journal of Medicine. 2002;346.
Du M-Q, Liu H, Diss TC, et al. “Kaposi sarcoma-associated herpesvirus infects monotypic (IgM-lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.” Blood. 2001;97.