FITC标记的OTOP3蛋白抗体
产品名称： FITC标记的OTOP3蛋白抗体
英文名称： Anti-OTOP3/FITC
产品编号： HZ-17536R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OTOP3/FITC Conjugated antibody
FITC标记的OTOP3蛋白抗体
| 英文名称 | Anti-OTOP3/FITC |
| 中文名称 | FITC标记的OTOP3蛋白抗体 |
| 别 名 | OTOP3; OTOP3_HUMAN; Otopetrin-3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OTOP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures. Subcellular Location: Membrane. Similarity: Belongs to the otopetrin family. Database links: Entrez Gene: 347741 Human SwissProt: Q7RTS5 Human Unigene: 454407 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
耳鸣肽是一种多跨膜结构域蛋白，具有保守的基因和蛋白质结构，可能参与耳蜗和耳石的形成。耳石位于内耳的耳囊和囊中，是一种复杂的碳酸钙生物矿物质，是正常重力和线性加速度感觉所必需的。眩晕和失去平衡可能是由于耳蜗移位引起的退行性变。otopetrin家族由OTP1、OTP2和OTP3三种蛋白组成。这些蛋白具有12个推测的跨膜结构域，它们聚集成三个OtopeTrin结构域（OD-Ⅰ、II和III）。OTop1是Otopetrin家族中第一个被描述的成员。OTop1的突变导致耳蜗或耳石的缺失，尽管内耳发育正常。OTOP2和OTOP3与OTOP1在构造上具有明显的相似性，在矿化构造的形成中也有一定作用。