FITC标记的γ-谷氨酰转肽酶6抗体
产品名称： FITC标记的γ-谷氨酰转肽酶6抗体
英文名称： Anti-GGT6/FITC
产品编号： HZ-13350R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GGT6/FITC Conjugated antibody
FITC标记的γ-谷氨酰转肽酶6抗体
| 英文名称 | Anti-GGT6/FITC |
| 中文名称 | FITC标记的γ-谷氨酰转肽酶6抗体 |
| 别 名 | Gamma glutamyltransferase 6 homolog; Gamma glutamyltranspeptidase 6; GGT 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GGT6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Gamma-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. Belonging to the gamma-glutamyltranspeptidase family, GGT6 (gamma-glutamyltransferase 6), is a 493 amino acid single-pass type II membrane protein that cleaves glutathione conjugates. GGT6 exists as two alternatively spliced isoforms. Function: GGT6 belongs to the gamma-glutamyltransferase family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis. GGT6 has very limited amino acid similarity to GGT1 and it's enzymatic activities are currently uncharacterized. GGT assays are of current widespread clinical use to help assess tissue damage. Subcellular Location: Membrane; Single-pass type II membrane protein. Database links: Entrez Gene: 124975 Human Omim: 612341 Human SwissProt: Q6P531 Human Unigene: 130749 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
γ-谷氨酰转肽酶（GGT）作为谷胱甘肽酶，催化谷胱甘肽的谷氨酰部分向多种氨基酸和二肽受体的转移。这种酶位于细胞膜的外表面，广泛分布在参与吸收和分泌的哺乳动物组织中。在人类中，肝GGT活性在某些肝脏疾病中升高。GGT1在肝损伤后被释放到血流中，并且酶的升高可能是肝细胞癌的有用的早期征兆。GGT5将白三烯C4转化为白三烯D4，但是它不能转化通常用于测定GGT的合成底物。在人血清和人体组织中，GGT具有明显的异质性，但这种异质性可归因于同一肽的不同糖基化，而不是归因于不同基因的产物。GGT6(γ-谷氨酰转肽酶6)属于γ-谷氨酰转肽酶家族，是一种493个氨基酸的单程II型膜蛋白，能裂解谷胱甘肽结合物。GGT6存在两个交替拼接的异构体。