FITC标记的卷曲螺旋结构域蛋白49抗体
产品名称： FITC标记的卷曲螺旋结构域蛋白49抗体
英文名称： Anti-CCDC49/FITC
产品编号： HZ-17611R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CCDC49/FITC Conjugated antibody
FITC标记的卷曲螺旋结构域蛋白49抗体
| 英文名称Anti-CCDC49/FITC中文名称FITC标记的卷曲螺旋结构域蛋白49抗体别 名Coiled-coil domain-containing protein 49; CWC25_HUMAN; Pre-mRNA-splicing factor CWC25 homolog. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域细胞生物 信号转导 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 产品应用ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量50kDa性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human CCDC49亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: Spliceosomes are large ribonucleoproteins that remove introns from nuclear pre-mRNA in a two-step reaction. CCDC49 is a 425 amino acid protein that is involved in the catalytic steps of splicing in Saccharomyces cerevisiae. CCDC49 associates with a component of the Prp19-associated complex, CEF1, which is involved in spliceosome activation. It is likely that CCDC49 facilitates juxtaposition of the 5’ splice site and branch point during the final step in the first catalytic reaction. There are two isoforms of CCDC49 that are produced as a result of alternative splicing events. Similarity: Belongs to the CWC25 family. Database links: Entrez Gene: 613278 Cow Entrez Gene: 91050 Human Entrez Gene: 100503884 Mouse Entrez Gene: 688939 Rat SwissProt: Q0VCP9 Cow SwissProt: Q6ZUS6 Human Unigene: 106432 Human Unigene: 332379 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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剪接体是在两步反应中从细胞核前mRNA中去除内含子的大核糖核蛋白。CCDC49是一个425个氨基酸的蛋白质，参与酿酒酵母的拼接步骤。CCDC49与Prp19相关复合物CEF1相关，其参与剪接体激活。在第一催化反应的最后步骤中，CCDC49可能促进5’接合位点和分支点的并置。CdcC49的两种异构体是作为选择性剪接事件的结果而产生的。