FITC标记的核RNA输出因子1抗体
产品名称： FITC标记的核RNA输出因子1抗体
英文名称： Anti-NXF1/FITC
产品编号： HZ-19553R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NXF1/FITC Conjugated antibody
FITC标记的核RNA输出因子1抗体
| 英文名称 | Anti-NXF1/FITC |
| 中文名称 | FITC标记的核RNA输出因子1抗体 |
| 别 名 | DKFZp667O0311; DmNXF1; MEX67; MEX67, yeast, homolog of; Mex67p; mRNA export factor TAP; Mvb1; Nuclear RNA export factor 1; Nuclear RNA export factor 1 homolog (S. cerevisiae); nxf 1; NXF1; NXF1_HUMAN; Protein small bristles; Sbr; TAP; Tip associating protein; Tip-associated protein; Tip-associating protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NXF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with THOC4 and THOC5. Subcellular Location: Nucleus > nucleoplasm. Nucleus speckle. Cytoplasm. Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Tissue Specificity: Expressed ubiquitously. Similarity: Belongs to the NXF family. Contains 4 LRR (leucine-rich) repeats. Contains 1 NTF2 domain. Contains 1 RRM (RNA recognition motif) domain. Contains 1 TAP-C domain. Database links: Entrez Gene: 10482 Human Entrez Gene: 53319 Mouse Entrez Gene: 59087 Rat Omim: 602647 Human SwissProt: Q9UBU9 Human SwissProt: Q99JX7 Mouse SwissProt: O88984 Rat Unigene: 523739 Human Unigene: 601546 Human Unigene: 7271 Mouse Unigene: 159847 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是核RNA输出因子基因家族中的一员。该家族的共同结构域特征是非典型RNP型RNA结合结构域(RBD)、4个富含亮氨酸的重复序列(LRR)、允许与NTF2相关的输出蛋白-1(NXT1)异二聚的核转运因子2(NTF2)样结构域以及介导中间体的泛素相关结构域。具有核孔蛋白的阳离子。LRRS和NTF2类结构域是导出活性所必需的。选择性剪接似乎是一个共同的机制，在这个基因家族。该基因编码的蛋白质在细胞核和细胞质之间穿梭，并在体内与聚（a）+RNA结合。它是酵母蛋白Mex67p的脊椎动物同源物，该编码蛋白克服了D型反转录病毒饱和量的CTE（组成转运元件）RNA引起的mRNA输出阻滞。选择性剪接导致多个转录变体。[ RefSeq，JUL 2008 ]