FITC标记的平滑肌蛋白LMOD2抗体
产品名称： FITC标记的平滑肌蛋白LMOD2抗体
英文名称： Anti-LMOD2/FITC
产品编号： HZ-18316R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LMOD2/FITC Conjugated antibody
FITC标记的平滑肌蛋白LMOD2抗体
| 英文名称 | Anti-LMOD2/FITC |
| 中文名称 | FITC标记的平滑肌蛋白LMOD2抗体 |
| 别 名 | C-LMOD; Cardiac leiomodin; Leiomodin 2 (cardiac); Leiomodin-2; LMOD2; LMOD2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 发育生物学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LMOD2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants. Function: May block the elongation and depolymerization of the actin filaments at the pointed end. Tissue Specificity: Specifically expressed in heart and skeletal muscles. Not expressed in other tissues. Similarity: Belongs to the tropomodulin family. Contains 1 WH2 domain. Database links: Entrez Gene: 442721 Human Entrez Gene: 93677 Mouse Omim: 608006 Human SwissProt: Q6P5Q4 Human SwissProt: Q3UHZ5 Mouse Unigene: 592260 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Leiomodin蛋白家族的成员与肌动蛋白丝端帽蛋白的tropomodulin家族密切相关。LeimoDin是肌动蛋白结合蛋白，在肌肉细胞中起着强丝成核作用。平滑肌素1在含有平滑肌的多种组织中高度表达，因此也称为平滑肌平滑肌平滑肌素或SM-Lmod。也指定C-LMOD，莱莫定3在几种类型的胎儿组织中发现，并参与原肌球蛋白结合。Leiomodin 2，又称C-LMOD或LMOD2，是一种547氨基酸蛋白，在心脏和骨骼肌中特异表达。LeimoDin 2与原肌球蛋白结合，可阻断肌动蛋白丝在其末端的伸长和解聚。Leiomodin 2是由位于7号染色体上肥厚性心肌病位点CMH6附近的基因编码的，表明Leiomodin 2可能参与了该疾病的过程。莱莫定2表达为三个交替剪接变异体。