HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)
产品名称: HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)
英文名称: HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
产品编号: TMPH-01522
产品价格: 500 μg
产品产地: 美国
品牌商标: TargetMol
更新时间: 2024-05-23T17:34:14
使用范围: null
规格 | 价格 |
11300.00 |
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Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.