HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)-有机试剂-试剂-生物在线
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HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)

HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)

商家询价

产品名称: HIV-2 (subtype A, isolate ROD) 重组蛋白 Vpx (His)

英文名称: HIV-2 (subtype A, isolate ROD) Protein Vpx (His)

产品编号: TMPH-01522

产品价格: 500 μg

产品产地: 美国

品牌商标: TargetMol

更新时间: 2024-05-23T17:34:14

使用范围: null

规格 价格
11300.00
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Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.