1) Cat. No.: TRC-B285725; 2) Chemical Name: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; 3) CAS No.: 327036-89-5; 4) Mol. Formula: C10H10N2O2S; 5) Mol. Weight: 222.26; 6) Packing Size: 10mg / 100mg; 7) Appearence: White Solid; 8) Application Notes: Glycogen Synthase Kinase-3 is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes.  TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3 ( IC50 =2nM).  Binds to the active site of GSK-3.  Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).; 9) Synonym: GSK-3 Inhibitor I, TDZD-8; 10) Solubility: Hexane; 11) Storage condition: -20°C Freezer; 12) References: Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)