FITC标记的激活STAT蛋白抑制因子4抗体
产品名称： FITC标记的激活STAT蛋白抑制因子4抗体
英文名称： Anti-PIAS4/PIASy/FITC
产品编号： HZ-14480R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PIAS4/PIASy/FITC Conjugated antibody
FITC标记的激活STAT蛋白抑制因子4抗体
| 英文名称 | Anti-PIAS4/PIASy/FITC |
| 中文名称 | FITC标记的激活STAT蛋白抑制因子4抗体 |
| 别 名 | E3 SUMO protein ligase PIAS4; E3 SUMO-protein ligase PIAS4; FLJ12419; MGC35296; PAIASgamma; PIAS 4; PIAS gamma; PIAS-gamma; PIAS4; PIAS4_HUMAN; PIASG; PIASgamma; PIASy; Protein inhibitor of activated STAT 4; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; Protein inhibitor of activated STAT protein PIASy; Zinc finger MIZ type containing 6; ZMIZ 6; ZMIZ6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 生长因子和激素 转录调节因子 表观遗传学 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PIASy |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The IL-6-type family of cytokines, which includes IL-6 and a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the STAT family are involved in IL-6 family-mediated signal transduction pathways, and upon activation undergo phosphorylation, dimerization and translocation to the nucleus. The duration and intensity of a cell's response to cytokines can be adjusted by the effect of several regulatory mechanisms. One example involves the protein inhibitor of activated signal transducer and activator of transcription (STAT) family (PIAS family) of proteins, which act as negative regulators of STATs in cytokine signaling. PIAS proteins are able to coactivate steroid receptor-dependent transcription as well. Human PIASy is a 510 amino acid transcriptional corepressor of the androgen receptor (AR). In addition, PIASy may regulate p53-mediated events and may direct p53 into a transactivation-independent mode of apoptosis. Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Subcellular Location: Nucleus > PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. Tissue Specificity: Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. Post-translational modifications: Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activitation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate. Similarity: Belongs to the PIAS family. Contains 1 PINIT domain. Contains 1 SAP domain. Contains 1 SP-RING-type zinc finger. Database links: Entrez Gene: 51588 Human Entrez Gene: 59004 Mouse Entrez Gene: 362827 Rat Omim: 605989 Human SwissProt: Q8N2W9 Human SwissProt: Q3UGQ2 Mouse SwissProt: Q9JM05 Mouse Unigene: 105779 Human Unigene: 34428 Mouse Unigene: 12810 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IL-6类细胞因子家族包括IL-6和一些相似的细胞因子和生长因子，在调节基因的活化、增殖和分化中起重要作用。STAT家族的转录因子参与IL-6家族介导的信号转导通路，在激活时经历磷酸化、二聚化和向细胞核的转移。细胞对细胞因子的反应的持续时间和强度可以通过几种调节机制的影响来调节。一个例子涉及激活信号转导子的蛋白抑制剂和蛋白质的转录激活子(STAT)家族(PIAS家族)，它们在细胞因子信号传导中起STAT的负调控作用。PIAS蛋白能够同时激活类固醇受体依赖的转录。人PIASY是雄激素受体（AR）的510氨基酸转录辅阻遏物。此外，PIAY可调节p53介导的事件，并可将p53直接导入反转录激活的细胞凋亡模式。