FITC标记的精子顶体膜相关蛋白1抗体
产品名称： FITC标记的精子顶体膜相关蛋白1抗体
英文名称： Anti-SPACA1/FITC
产品编号： HZ-17614R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SPACA1/FITC Conjugated antibody
FITC标记的精子顶体膜相关蛋白1抗体
| 英文名称 | Anti-SPACA1/FITC |
| 中文名称 | FITC标记的精子顶体膜相关蛋白1抗体 |
| 别 名 | SACA1_HUMAN; SAMP32; SPACA1; Sperm acrosomal membrane-associated protein 32; Sperm acrosome membrane-associated protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPACA1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008] Function: May be involved in sperm-egg fusion. Subcellular Location: Membrane. Tissue Specificity: Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm. Database links: Entrez Gene: 81833 Human Omim: 612739 Human SwissProt: Q9HBV2 Human Unigene: 161241 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
抗精子抗体与不明原因不孕症的相关性提示这些抗体在阻断受精中的作用。提高免疫性不孕的诊断和治疗，以及鉴定用于定向避孕的蛋白质，取决于相关精子抗原的鉴定和特征。这种基因表达的蛋白质是由不育男性的抗精子抗体所识别的。此外，在体外受精中对重组蛋白块产生抗体。该蛋白定位于精子顶体膜和成熟精子，被认为分别在顶体形态发生和精子-卵结合和融合中发挥作用。[ RefSeq，JUL 2008 ]