CYP11A1 Pre-design Chimera RNAi
产品名称： CYP11A1 Pre-design Chimera RNAi
英文名称： CYP11A1 Pre-design Chimera RNAi
产品编号： H00001583-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
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- Specification
- Product Description:
- Homo sapiens cytochrome P450, family 11, subfamily A, polypeptide 1 (CYP11A1), nuclear gene encoding mitochondrial protein, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000781
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1583
- Gene Name:
- CYP11A1
- Gene Alias:
- CYP11A,P450SCC
- Gene Description:
- cytochrome P450, family 11, subfamily A, polypeptide 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq
- Other Designations:
- cholesterol 20-22 desmolase,cholesterol monooxygenase (side-chain cleaving),cytochrome P450, subfamily XIA,cytochrome P450, subfamily XIA (cholesterol side chain cleavage),cytochrome P450C11A1,steroid 20-22-lyase
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Asperger Syndrome
- Autistic Disorder
- Breast cancer
- Breast Neoplasms
- Breast Neoplasms, Male
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Celiac Disease
- Colorectal Neoplasms
- Disease Progression
- Ductus Arteriosus, Patent
- Endometrial Neoplasms
- Fibrocystic Breast Disease
- Genetic Predisposition to Disease
- Genital Neoplasms, Male
- Hyperandrogenism
- Hypertension
- Infant, Premature, Diseases