高血压基因表达PCR芯片

 高血压基因表达PCR芯片可检测对多种信号有反应的，调控血管收缩和扩张生物通路的84个关键基因的表达。芯片可以用于检测分析与高血压关联的器官和组织，包括：心脏、肾脏、肝脏、肺，以及含有毛细血管和平滑肌的活检组织。综合分析这些基因的表达，是解密高血压发生和发展的分子机制，以及并发心血管疾病分子机制的有效方法。利用该芯片研究者即能够利用该芯片简单可靠地同时检测高血压相关的基因表达。

Vasodilation: ACE, ACE2, ADM, ADRB1, AGTR1, AGTR2, CALCA, CPS1, EDNRB, EPHX2, GCH1, KCNJ8, KNG1, NOS3, NPPB, NPPC, NPR1, P2RX4, PDE5A.

Vasoconstriction: ACE, ACE2, ADM, ADRA1B, AGT, AGTR1, ALOX5, AVP, AVPR1A, BDKRB2, BMPR2, CACNA1C, CAV1, ECE1, EDN1, EDN2, EDNRA, EDNRB, NPPC, NPY1R, PTGS1, PTGS2, UTS2R.

Vasotone: AGTR1, DRD3, NOS3, NPPB, NPPC, REN.

Smooth Muscle Contraction: ACTA2, ADRA1B, ADRB1, BDKRB2, CACNA1C, CAV1, EDN1, EDN2, EDNRA, EDNRB, KCNMA1, KNG1, P2RX4, PTGS1, PTGS2, UTS2.

Smooth Muscle Relaxation: GUCY1A3, KCNMA1, P2RX4. Myosin Light

Chain Kinases: MYLK, MYLK2, MYLK3.

Blood Pressure Regulation: ACE, ACE2, ACTA2, AGT, AGTR2, AVP, AVPR1A, AVPR1B, BDKRB2, CACNA1C, CALCA, DRD3, DRD5, ECE1, EDN1, EDN2, EDNRB, EPHX2, GCH1, GUCY1A3, NOS3, NPPB, NPPC, NPR1, NPY1R, P2RX4, PTGS1, PTGS2, REN, UTS2, UTS2R.

Renin-Angiotensin System: ACE, ACE2, AGT, AGTR1, ECE1, REN.

Nitric Oxide Signaling: AGT, AGTR2, GUCY1A3, GUCY1B3, NOSIP, NOSTRIN.

Nitric Oxide Metabolism: AGTR2, ARG2, CAV1, CPS1, EDN1, GCH1, GCHFR, HIF1A, NOS3, P2RX4.

Cyclic-GMP Synthesis & Signaling: ADRA1D, GUCY1B3, PDE3B, PRKG1, PRKG2, PTGIR, S1PR1.

Osmotic Shock: AGT, AVP, AVPR1B, BDKRB2, KCNMA1.

Hypoxia Response: ACE, ADM, CAV1, ECE1, EDN1, EDNRA, HIF1A, KCNMA1, NOS3, NPPC, PDE5A.

Second-Messenger-Mediated Signaling: ADRA1D, PDE3B, PTGIR, S1PR1, SPHK1.

Ion Transport: ATP2C1, ATP6AP2, BDKRB1, CHRNA1, CHRNB1, CLIC1, CLIC4, CLIC5, CNGA1, CNGA2, CNGA3, CNGA4, CNGB1, CNGB3, ITPR1, ITPR2, PLCG2, SCNN1A, SCNN1B, SCNN1G, SLC7A1.

Lipid Metabolism: PDE3A, PDE3B, PLCG1, PLCG2, SPHK1, SPHK2.