FITC标记的8号染色体开放阅读框80抗体
产品名称： FITC标记的8号染色体开放阅读框80抗体
英文名称： Anti-C8orf80/FITC
产品编号： HZ-20053R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C8orf80/FITC Conjugated antibody
FITC标记的8号染色体开放阅读框80抗体
| 英文名称 | Anti-C8orf80/FITC |
| 中文名称 | FITC标记的8号染色体开放阅读框80抗体 |
| 别 名 | C8orf80; GTPase SLIP-GC; SLIP_HUMAN; Speckled-like pattern in the germinal center. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C8orf80 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. The C8orf80 gene product has been provisionally designated C8orf80 pending further characterization. Function: Plays a role as replication-related GTPase protein in germinal center B-cell. Subcellular Location: Nucleus. Tissue Specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell. Database links: Entrez Gene: 389643 Human SwissProt: Q68CJ6 Human Unigene: 370129 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
由近1亿4600万个碱基组成，8号染色体编码约800个基因。在一些白血病和淋巴瘤中发现第8染色体部分易位，并伴有c-Myc基因的扩增，并且通常与较差的预后相关。8号染色体的部分与精神分裂症和双相情感障碍有关。8三体，也称为Warkany综合征2，通常导致早期流产，但偶尔在幸存的患者中以马赛克形式出现，这些患者患有不同程度的症状，包括智力和运动发育迟缓，以及某些面部和发育缺陷。WRN是由8号染色体编码的DNA解旋酶，在早期衰老障碍沃纳综合征中显示出缺陷。第8号染色体也与菲佛综合征、先天性甲状腺功能减退症和Waord-Burg综合征有关。c8Orf80基因产物已暂时指定为C8ORF 80，有待进一步鉴定。