FITC标记的神经突起生长诱导因子受体UNC5B抗体
产品名称： FITC标记的神经突起生长诱导因子受体UNC5B抗体
英文名称： Anti-UNC5C/FITC
产品编号： HZ-11493R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-UNC5C/FITC Conjugated antibody
FITC标记的神经突起生长诱导因子受体UNC5B抗体
| 产品编号 | bs-11493R-FITC |
| 英文名称 | Anti-UNC5C/FITC |
| 中文名称 | FITC标记的神经突起生长诱导因子受体UNC5B抗体 |
| 别 名 | UNC5H3; Alternative nameshomolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc 5 homolog C; Unc 5 homolog 3; Unc 5 homolog C; Unc5 (C.elegans homolog) c; UNC5H3; UNC5C_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 1 |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 99kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UNC5H3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] Function: UNC5C is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It is also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. There are two named isoforms. Subunit: Interacts with the cytoplasmic part of DCC Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. Post-translational modifications: Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent (By similarity). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis Similarity: Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 TSP type-1 domains. Contains 1 ZU5 domain. Database links: Entrez Gene: 8633 Human Entrez Gene: 22253 Mouse Entrez Gene: 362049 Rat Omim: 603610 Human SwissProt: O95185 Human SwissProt: O08747 Mouse SwissProt: Q761X5 Rat Unigene: 388565 Human Unigene: 24430 Mouse Unigene: 47255 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因产物属于NETCR受体的UNC-5家族。NeTrin是分泌蛋白，在神经发育过程中直接促进轴突延伸和细胞迁移。它们是双功能蛋白，作为某些细胞类型的引诱剂，对其他细胞起排斥作用，而这些相反的作用被认为是由两类受体介导的。UNC-5受体家族介导了对NeTrin的排斥反应，它们是跨膜蛋白，含有2个免疫球蛋白（Ig）样结构域和2个I型血小板反应素基序。