FITC标记的环指蛋白35抗体
产品名称： FITC标记的环指蛋白35抗体
英文名称： Anti-RNF35/FITC
产品编号： HZ-9237R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RNF35/FITC Conjugated antibody
FITC标记的环指蛋白35抗体
| 产品编号 | bs-9237R-FITC |
| 英文名称 | Anti-RNF35/FITC |
| 中文名称 | FITC标记的环指蛋白35抗体 |
| 别 名 | RING finger protein 35; Gm319; Gm35; Gm865; ring finger protein 40; Ring finger RNF35; TRIM40; Tripartite motif containing 40; Tripartite motif containing protein 40; Tripartite motif protein 40; TRI40_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF35 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM61 (Tripartite motif-containing protein 61), also known as RNF35 (RING finger protein 35), is a 209 amino acid protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. In mice, TRIM61 is temporarily transcribed in the early embryo, but then is permanently silenced before the blastocyst stage of development. Transcription of TRIM61 is positively regulated by nuclear factor Y (NF-Y). The gene encoding TRIM61 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Function: May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. Subunit: Interacts with NEDD8. Tissue Specificity: Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger. Database links: Entrez Gene: 135644 Human Entrez Gene: 195359 Mouse Entrez Gene: 365528 Rat SwissProt: Q6P9F5 Human SwissProt: Q3UWA4 Mouse SwissProt: Q6MFY8 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白质的三部分基序（TIM）的特征在于保守的修剪域，其包括卷曲线圈区域、B-盒型锌指、一个环指和三个锌结合域。Trim61（第三部分含基序蛋白61），也称为RNF35（环指蛋白35），是含有修饰环蛋白特征的各种域的209氨基酸蛋白，包括环状锌指和B盒型锌指。在小鼠中，Trim61在早期胚胎中被暂时转录，但是在发育囊胚阶段之前被永久地沉默。Trim61转录受核因子Y（NF- Y）的正向调控。编码Trim61的基因编码到人类4号染色体上，编码人类近6%的基因组，并具有所有人类染色体上最大的基因沙漠（没有编码基因的基因组区域）。