FITC标记的二肽基肽酶8抗体
产品名称： FITC标记的二肽基肽酶8抗体
英文名称： Anti-DPP8/FITC
产品编号： HZ-8295R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DPP8/FITC Conjugated antibody
| FITC标记的二肽基肽酶8抗体 |
| 产品编号 | bs-8295R-FITC |
| 英文名称 | Anti-DPP8/FITC |
| 中文名称 | FITC标记的二肽基肽酶8抗体 |
| 别 名 | Dipeptidyl peptidase 8; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; DP8; DPRP-1; EC 3.4.14.5; Prolyl dipeptidase DPP8; DPP8_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 发育生物学 信号转导 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 103kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPP8/DPRP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPRP1 (dipeptidyl-peptidase IV-related protein 1), also known as DPP8 (dipeptidyl-peptidase 8), DP8 or MSTP141, is a member of the peptidase S9B family of proteins that exhibit prolyl oligopeptidase activity. DPRP1 localizes to the cytoplasm and is ubiquitously expressed with predominant expression in placenta, brain, prostate, testis and muscle. DPRP1 is similar to CD26 (dipeptidyl peptidase IV) suggesting that it may be involved in immune function and participate in the activation of T-cells. Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Subcellular Location: Cytoplasmic Tissue Specificity: predominant expression in placenta, brain, prostate, testis and muscle. Similarity: Belongs to the peptidase S9B family. DPPIV subfamily. Database links: UniProtKB/Swiss-Prot: Q6V1X1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Dipeptidyl peptidases（DPPS）介导了其底物的调节活性，并与多种疾病相关，包括2型糖尿病、肥胖和癌症。DPPS具有脯氨酸二肽基氨基肽酶活性，从蛋白质的N端裂解XAA脯氨酸二肽。DPPS可以结合特定的电压门控钾通道，并改变其表达和生物物理性质，也可能影响T细胞。DPP蛋白包括DPRP1、DPRP2、DPP3、DPP7、DPP10、DPPX和CD26。DPRP1（二肽基肽酶IV相关蛋白1），也称为DPP8（二肽基肽酶8）、DP8或MSTP141，是肽脯酶S9B家族的成员，其具有脯氨酰寡肽酶活性。DPRP1定位于细胞质，广泛表达于胎盘、脑、前列腺、睾丸和肌肉中。DPRP1与CD26（二肽基肽酶IV）相似，提示它可能参与免疫功能并参与T细胞的活化。