FITC标记的ADP核糖基化因子5抗体-抗体-抗体-生物在线
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FITC标记的ADP核糖基化因子5抗体

FITC标记的ADP核糖基化因子5抗体

商家询价

产品名称： FITC标记的ADP核糖基化因子5抗体

英文名称： Anti-ARF5/FITC

产品编号： HZ-12511R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-ARF5/FITC Conjugated antibody

FITC标记的ADP核糖基化因子5抗体

 

英文名称 Anti-ARF5/FITC
中文名称 FITC标记的ADP核糖基化因子5抗体
别    名 ADP ribosylation factor 5; ADP-ribosylation factor 5; ARF 5; Arf5; ARF5_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARF5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association of actin to the golgi via rho family-dependent G-protein localization (Rac, CDC42) and WASP/Arp2/3 complexes. Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins, and activation of phospho-lipase D. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6); members of each class share a common gene organization.

Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Subunit:
Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.

Subcellular Location:
Golgi apparatus. Cytoplasm > perinuclear region.

Similarity:
Belongs to the small GTPase superfamily. Arf family.

Database links:
UniProtKB/Swiss-Prot: P84085.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

ADP-核糖基化因子（ARF）蛋白家族是调节性GTP结合蛋白的Ras超家族中结构和功能保守的成员。ARFs对真核细胞囊泡运输和信号转导的影响ARF依赖的调节机制包括通过rho家族依赖的G-蛋白定位(Rac，CDC42)和WASP/Arp2/3复合物协调与高尔基体膜的光谱相互作用以及肌动蛋白与高尔基体的结合。此外，ARF在维持细胞器完整性、外壳蛋白的组装和磷脂酶D的激活方面起着重要作用。ARF蛋白分为Ⅰ类（ARF1、ARF2和ARF3）、Ⅱ类（ARF4和ARF5）和三类（ARF6）；重组。