分子量：Calculated MW: 48kDa/115kDa
Observed MW: 116kDa

细胞定位：Mitochondrion matrix

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100

总结：This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.