小鼠抗人CD16单克隆抗体


CD16, the low affinity Fc gamma receptor III for IgG (Fc RIII), exists both as a polypeptide-anchored form (Fc RIIIA or CD16-A) in human natural killer cells and macrophages and as a glycosylphosphatidylinositol-anchored form (FcRIIIB or CD16-B) in neutrophils. CD16-A requires association of the ? subunit of FcéRI or the Ω subunit of the TCR-CD3 complex for cell surface expression. CD16-B is polymorphic; the two alleles are termed NA1 and NA2 . CD16 is one of only four eukaryotic receptors known to exist natively in both the transmembrane (TM, CD16-A) and glycosylphosphatidylinositol (GPI, CD16-B) isoforms. Patients with paroxysmal nocturnal haemoglobinuria (PNH) have only about 10% of the normal levels of CD16 on their neutrophils, whereas the expression of FcRII is unaffected. Analysis of FcRIII expression in cells of PNH patients, known to be deficient in PI-linked proteins, suggests FcRIII is not PI-linked in monocytes.
小鼠抗人CD16单克隆抗体为一种高质量小鼠单克隆抗体制剂，该抗体与CD16特异结合，用于检测人CD16的检测。

小鼠抗人CD16单克隆抗体技术参数
免疫原：人CD16
抗体宿主：小鼠
制备方法：蛋白A亲和层析纯化腹水抗体
制剂配方：0.1M Glycine-HCl, 1.5 mg/ml HSA, pH7.4
内毒素水平：＜0.25 Eu/ml
纯度：＞95％

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