重组人MERTK(酪氨酸蛋白激酶Mer)

中文名称：重组人MERTK(酪氨酸蛋白激酶Mer)
英文名称：Recombinant Human Tyrosine-protein kinase Mer
产品规格：10μg|50μg|500μg|1mg
 

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Met177-Ala499在C端含有His标签。

MERTK质量控制：＞95%(还原性SDS-PAGE)

MERTK制剂：冻干品

MERTK保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

MERTK复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于MERTK：

Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines.MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganization. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE)， deficiency in MERTK are the cause of retinitis pigmentosa.

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！